Sissoko was substituted during Saturday's Premier League win at Middlesbrough with concussion.
Spurs boss Mauricio Pochettino provided an update on his team news which the club announced on Twitter.
Harry Kane (ankle), Eric Dier, Mousa Dembele and Danny Rose (all hamstring) also did not travel.
"Mauricio confirms that @HKane, @ericdier, @mousadembele, Danny Rose and @MoussaSissoko haven't travelled to Moscow due to injury," the club tweeted.
Spurs are bottom of Group E after losing their opening game to Monaco at Wembley and play Manchester City in the Premier League on Sunday.
Source : PA
Source: PA