Tottenham manager Mauricio Pochettino must decide whether to shuffle his pack for the clash with Southampton.
With less than 72 hours between matches, the Spurs boss could be tempted to utilise his squad, although one player certain to start is Harry Kane as he chases the one goal he needs to set a new Premier League era scoring record for a single year.
Toby Alderweireld (hamstring) and Victor Wanyama (knee) both remain sidelined.
Southampton will be without forward Charlie Austin.
The 28-year-old, has been banned for three games by the Football Association for kicking Huddersfield goalkeeper Jonas Lossl.
Ryan Bertrand (hamstring) and Cedric Soares (ankle) are both doubts for Mauricio Pellegrino's side.