As well as scoring his 100th league goal on Saturday, the 24-year-old is also recognised for being the Republic of Ireland's highest ever goalscorer, after he took his international tally to 24 goals earlier this season.
Keane, who had been linked with a possible transfer to David O'Leary's Aston Villa in the January window, is set to scoop Ireland's top prize for an individual player ahead of compatriots Kevin Kilbane and Shay Given.
Meanwhile, Tottenham are hoping they will have all three in-form strikers available to face Chelsea at White Hart Lane this Saturday. Fredi Kanoute is expected to return from the hamstring injury, which forced him to miss the 0-0 draw at Manchester United in the Premiership and the FA Cup third round tie with Brighton last weekend.
Keane, Kanoute, and Jermain Defoe have scored 20 of Tottenham's 29 league goals and a further 11 of the 15 scored in cup competitions so far this season.
"They all want to score goals and you want them to have the hunger and desire to do that all the time. We're just thankful for the individual quality we have at the club," said assistant manager Chris Hughton.