Spurs have been left with a mountain to climb to reach the last four of the competition after going down 4-0 at the Bernabeu, but Pulis feels anything could happen in next Wednesday's return encounter at White Hart Lane if Harry Redknapp's team make a flying start.
"Harry will be absolutely devastated because he would have been going there hoping to get close and bring them back to White Hart Lane with a chance," Pulis said.
"I think that circumstances on the pitch have changed that and he will need a monumental effort now from his players and the supporters.
"But it is an old-fashioned ground, a fantastic ground to play at with a fantastic atmosphere, and you never know.
"If they get a couple of goals early on, things could conspire their way and Harry will make sure they are at it without a question of a doubt."
Source: PA
Source: PA