Spurs, currently seventh in the Premier League, need to overhaul a one-point difference between themselves and Wolves - who face Chelsea at Stamford Bridge - to reach Europe.
Palace's wretched run of form has seen them drop out of the top ten and into 14th, though the Eagles could rise a place if they beat Tottenham and Newcastle lose to Liverpool.
Where to Watch
Palace's absentees list is pretty long, with Patrick van Aanholt, James Tomkins, Mamadou Sakho and Gary Cahill all unavailable.
Christian Benteke is suspended, but Luka Milivojevic may hope to play some part if he can recover from the knee problem which kept him out of the Wolves loss.
Jose Mourinho has confirmed Tanguy Ndombele is the only absentee from his squad, with Dele Alli fit and available again having recovered from a hamstring injury. Eric Dier is back following suspension.
The XI is likely to be similar to the one that dispatched Leicester 3-0 last time out, with Son Heung-min up front alongside Harry Kane.
Crystal Palace: Guaita; Ward, Kouyate, Dann, Mitchell; Townsend, McCarthy, McArthur, Schlupp; Zaha, Ayew.
Tottenham: Lloris; Aurier, Sanchez, Alderweireld, Davies; Sissoko, Winks, Lo Celso, Lucas; Kane, Son.
Palace's recent results do not read well. They've lost their last seven games, which would be relegation form if they hadn't secured four wins on the bounce prior to and after football's hiatus.
They've lost to Liverpool, Burnley, Leicester, Chelsea, Aston Villa, Manchester United and Wolves, scoring just twice in the process.
After some dispiriting performances and results against Sheffield United and Bournemouth, Spurs have looked better in recent weeks. Kane has been sharp in wins against Newcastle and Leicester, while Tottenham also disposed of Arsenal in the north London derby.
Below is each side's last five results.
Wolves 2-0 Crystal Palace (20/7)
Crystal Palace 0-2 Manchester United (16/7)
Aston Villa 2-0 Crystal Palace (12/7)
Crystal Palace 2-3 Crystal Palace (7/7)
Leicester 3-0 Crystal Palace (4/7)
Tottenham 3-0 Leicester (19/7)
Newcastle 1-3 Tottenham (15/7)
Tottenham 2-1 Arsenal (12/7)
Bournemouth 0-0 Tottenham (9/7)
Tottenham 1-0 Everton (6/7)
Even the most pessimistic Tottenham fan has to be confident here. The Eagles' performances have been terrible in recent weeks, while Spurs are starting to respond to Mourinho's tactics.
The north London outfit should win here, though whether it'll be enough for sixth place depends on Wolves' result at Stamford Bridge.
Prediction: Crystal Palace 1-3 Tottenham
Source : 90min