The England striker has been sidelined for just over two months following surgery on damaged ankle ligaments.
Defoe returned to training almost a month ahead of schedule and is available to face the Gunners.
Spurs boss Harry Redknapp said: "It's great to have him back.
"He's a fantastic goalscorer and he's different to anybody else.
"He certainly would've had six or seven goals by this stage of the season."
Source: PA
Source: PA