Defoe begins a three-match ban after receiving a straight red card for violent conduct in the 2-1 win at Aston Villa and is set to be replaced by Peter Crouch or Roman Pavlyuchenko.
Midfielder Luka Modric was forced off with cramp late on but should figure while defender William Gallas remains a doubt with a hamstring injury sustained over a fortnight ago.
Source: PA
Source: PA