Harry Redknapp's side reached the Carling Cup final in both 2008 and 2009, and will be hoping they can make home advantage count by securing a semi-final tie with crisis club Portsmouth.
In the original game at Craven Cottage, Spurs held Roy Hodgson's men to a 0-0 bore draw but there must be a winner tonight - even if extra-time and penalties are required.
With the Lilywhites currently occupying fourth spot in the league, it will be interesting to see if Redknapp resists the urge to rest players ahead of back-to-back clashes with Arsenal, Chelsea and Manchester United in April.
Opponents Fulham are safely mid-table and although they still have Europa League fixtures to contend with, Hodgson should name a full-strength side tonight.
Spurs striker Roman Pavlyuchenko is doubtful after picking up a hamstring injury in the weekend win over Stoke, while Jermaine Defoe is definitely ruled out with a similar problem.
David Rose and David Bentley could both be passed fit after training yesterday, while Tom Huddlestone could make his return from an ankle ligament injury.
Wilson Palacios looks set to return to the centre of midfield after being rested but Younes Kaboul is cup-tied after appearing for Portsmouth earlier in the competition.
Jonathan Woodgate and Carlo Cudicini are still absent with long-term injuries.
Visitors Fulham hope to have central defender Brede Hangeland available after he missed Sunday's defeat to Manchester City with a chest injury.
Andrew Johnson and John Pantsil are still suffering with injury and will both miss out.
Source: DSG
Source: DSG