Striker Peter Crouch is suspended after receiving a red card early on in the first leg, which Tottenham lost 4-0.
Tom Huddlestone and Younes Kaboul are likely to feature after returning from injury in the Premier League win over Stoke.
Spurs boss Harry Redknapp confirmed that Lennon is set to finally face Real.
"Aaron wasn't well again on Friday and not well enough to play against Stoke," he said.
"He did some work on Friday with the fitness coach and then joined in with a little game but didn't feel well enough.
"I think he will be fit enough to play on Wednesday.
"The crowd already know that we will give it a hell of a go."
Source: BBC Sport
Source: BBC Sport